This study aims to determine the effect of Capital Adequacy Ratio (CAR), Operational Costs Operating Income (BOPO), Net Interest Margin (NIM), Non Performing Loan (NPL), Loan Deposit Ratio (LDR), interest rates and exchange rates on bank profitability listed on the Indonesia Stock Exchange for the period 2015 - 2018. The object of this study is banking companies listed on the Indonesia Stock Exchange in 2015 - 2018, in this study using 18 samples of banking companies. Data collection techniques using the method of puposive sampling, while the data analysis technique used in this study is using the regredi model. The analysis shows that CAR, BOPO, NIM, NPL, LDR, interest rates and exchange rates are accepted together. Whereas for CAR partially positive and not significant effect on profitability, BOPO, LDR and the exchange rate have a negative and significant effect on profitability, NPL has a negative and not significant effect on profitability, NIM and interest rates have a positive and significant effect on profitability.