The study aimed to analyze the influence of Capital Adequacy Ratio (CAR), Non Performing Financing (NPF), Financing to Deposit Ratio (FDR), Operational Efficiency (BOPO), and Inflation toward the Return On Asset (ROA) of Islamic Banking in Indonesia. The subjects of this study were Islamic Banks registered with the Financial Services Authority (OJK) in the 2015-2019 period. the analysis method used the multiple regression analysis to test the hypothesis was t test and F test. The Result of this study showed that CAR, NPF, FDR, BOPO variables had significant effect on the ROA of Islamic Banks, while Inflation did not have significant effect on the ROA of Islamic Banks