The prevalence of acute respiratory tract infections (ISPA) in Indonesia reached 25% with an incidence range of 17.5%-41.4%. ARI attacks many children. Treatment is given in the form of antibiotics and given other drugs. First-line therapy for ISPA patients is given Amoxicillin antibiotics. Antibiotics are given in the form of pulver dosage form with a percentage of 71%, semi-solid preparations 21.8%, 7.2% liquid. Based on the results of a survey at the Banyumas District Health Center, preparations that are often formulated for pediatric ARI patients are pulveres needed from antibiotic tablets which are crushed and added with other drugs. Based on this, it is necessary to discuss the sensitivity of antibiotics in pulverized preparations and finished drugs to bacteria in the sputum of a child ARI patient in the Banyumas District Health Center. Method: The method used is the diffusion method so that the sample used is pulveres and sputum of a child ARD patient in Banyumas District Health Center and analyzed using antibiotic inhibition measurements. Results: this study showed the presence of bacterial causes of ARI in sputum of patients in Banyumas District Health Center. The bacteria found are Streptococcus pneumonia, Sthapylococcus aureus, Klabsiella pneumonia. Descriptive results show that Streptococcus pneumonia bacteria are sensitive and resistant, Sthapylococcus aureus is resistant and Klabsiella pneumonia is sensitive. Kruskal-Wallis Based Analysis shows significant differences between antibiotic sensitivity and finished drugs. The results of the analysis showed a weak relationship between sensitivity and resistance to the preparation of antibiotics and finished drugs at the Banyumas District Health Center. Conclusion: Antibiotics with non-compounding treatment have greater inhibition than concoctions and have a very weak relationship between sensitivity and resistance.