This study aims to find empirical evidence of the effect of Islamic social reporting (ISR) analysis, buying and selling, operating expenses and operating income (BOPO), third party funds (TPF) on profitability. The sample in this study were Islamic Commercial Banks registered with the Financial Services Authority in 2014-2019 using the purposive sampling method and obtained 12 Islamic commercial banks as samples with 72 observational data. The data analysis technique used is multiple linear regression analysis with the SPSS 23 test tool. The results of this study indicate that Islamic social reporting (ISR) and buying and selling financing have a positive effect on profitability. Meanwhile, operating expenses and operating income (BOPO) and third party funds (DPK) have no effect on profitability.