FORMULASI SEDIAAN GEL DARI NANOPARTIKEL EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L) SEBAGAI ANTIINFLAMASI

ADRIANA, EKA FITRI (2021) FORMULASI SEDIAAN GEL DARI NANOPARTIKEL EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L) SEBAGAI ANTIINFLAMASI. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Inflammation is the immune system's response to infection and tissue damage. Conventional drugs that are commonly used as anti-inflammatory drugs are class NSAIDs (Nonsteroidal Anti-inflammatory Drugs). Apart from having a therapeutic effect, drugs of this class generally have side effects, namely they can irritate the stomach or intestines which is sometimes accompanied by anemia due to blood loss. So it is necessary to find alternative treatments in treating pain and inflammation with relatively minor side effects. Soursop leaves (Annona muricata Linn.) Are a part of the soursop plant which is an herbal plant that has many properties, one of which is anti-inflammatory. The results of the isolation and identification of active chemical compounds as anti-inflammatory from the ethanol fraction of soursop leaves (Annona muricata Linn.) Are thought to be Gigantetrocin A. Method: The nanoparticles of ethanol extract of soursop leaves were made by ionic gelation method. Then for the anti-inflammatory test using the method of forming edema on the soles of the rats 'feet by using carrageenan to induce the emergence of edema on the rats' feet. Result: Clarity test 95.9. 1.58μm PSA test ,. Potential Zeta Test = 75.5 mV. The anti-inflammatory test from the results obtained shows that the nanoparticle gel preparation of ethanol extract of soursop leaves can have an anti-inflammatory effect, which is seen from the decrease in the volume of edema in rats' feet that have been induced by carrageenan.

Item Type: Thesis (Bachelor)
Uncontrolled Keywords: Nanoparticles, Anti-inflammatory, Soursop leave, Gigantetrocin A
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi S1
Depositing User: wulan
Date Deposited: 30 Mar 2022 01:17
Last Modified: 14 May 2024 02:06
URI: https://repository.ump.ac.id:80/id/eprint/11206

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