The study was conducted to determine the effect of fertilizers and frequency of weeding on the growth and yield of green spinach. It was conducted for 30 days with a randomized block design (RBD) 2 factors repeated 3 times. The combination of fertilizer treatment and frequency of weeding had a significant effect on spinach dry weight, frequency of weeding on spinach wet weight and had no significant effect on other observed variables. The highest dry weight of spinach was 22.33 grams, namely the POC treatment (P2) and 1-time weeding frequency treatment (S1) resulted in a dry weight of 18.93 grams.