The debate between the pro-vaccination and vaccination counter parties are fairly common in social media that make public dilemma. The research result Sulistiyani et al., (2017) and Rusharyati et al., (2017) stated that there is still a view of the subject of studies that the immunization unlawful. This can have an impact on the public rejection of the immunization program created by the government. This study aims to measure the picture of perceptions and attitudes towards halal vaccines in the clinic Purwokerto. This study using cross sectional approach in the period between February and April. This study includes qualitative and quantitative descriptive study using purposive sampling technique using questionnaires and interviews. The research result obtained is perception of respondents, 68 respondents (70.8%) and the attitude of the respondent as much as 59 respondents (61.5%). The statistical results of Spearman's correlation test showed that there was a strong relationship between perception and attitudes with p-value <0.05 (r = 0646, p = 0.000). Correlation coefficient is positive, then the relationship of perception and attitude direction. Based on the results of this study concluded that the public has a good view and the reaction with issue of halal vaccines and better perception of respondents that will affect their attitudes are good. Correlation coefficient is positive, then the relationship of perception and attitude direction. Based on the results of this study concluded that the public has a good view and the reaction terhadapi issue of halal vaccines and better perception of respondents that will affect their attitudes are good. Correlation coefficient is positive, then the relationship of perception and attitude direction. Based on the results of this study concluded that the public has a good view and the reaction with issue of halal vaccines and better perception of respondents that will affect their attitudes are good.