OPTIMASI SAMBUNG SILANG POLIVINIL ALKOHOL DAN NATRIUM ALGINAT SERTA PEG 400 SEBAGAI PLASTICIZER PADA WOUND DRESSING EKSTRAK IKAN GABUS (Channa striata)

ANGGITA, ESTI (2020) OPTIMASI SAMBUNG SILANG POLIVINIL ALKOHOL DAN NATRIUM ALGINAT SERTA PEG 400 SEBAGAI PLASTICIZER PADA WOUND DRESSING EKSTRAK IKAN GABUS (Channa striata). Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Background: Cork fish extract has high potential to accelerate the wound healing process because it contains high protein and albumin. The cork fish extract is formulated into a wound dressing by composition optimizing of PVA, sodium alginate, and PEG 400. In wound dressing applications, PVA is a synthetic hydrogel product that has good biocompatibility, but PVA is not elastic enough, the membrane is rigid and its hydrophilicity is limited if used singly. Therefore, a PVA crosslink was performed with sodium alginate to increase the elasticity of the wound dressing. Method: The crosslink method used was freeze-thaw with a freezing process at -20 ℃ for 18 hours and melting at 25 ℃ for 6 hours. In this research, optimization was carried out using the D-optimal design method. The optimum formula is obtained based on the desirability value which is close to 1. Results: The results showed that the optimum formula for wound dressing of cork fish extract with a composition of PVA 8.363%, 2.5% sodium alginate and 4.137% PEG 400 with a desirability value was 0.806. In the wound dressing formula, the tensile strength response was 3,390 N / mm2, the elongation at break response was 33.427%, and the young modulus was 10.101 mPa. Conclusion: Based on the research results, it can be concluded that the optimum formula obtained has the best response value, namely the formula with the composition of PVA 8.363%, 2.5% sodium alginate and PEG 400 4.137%.

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