PROFIL DISOLUSI TERBANDING TABLET GLIBENKLAMID PADA PRODUK GENERIK DENGAN MERK DALAM LARUTAN DAPAR FOSFAT PH 6, 8

KHUSSARIROH, IFTITA (2018) PROFIL DISOLUSI TERBANDING TABLET GLIBENKLAMID PADA PRODUK GENERIK DENGAN MERK DALAM LARUTAN DAPAR FOSFAT PH 6, 8. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

[img]
Preview
Text
COVER_IFTITA KHUSSARIROH_FARMASI'18.pdf

Download (647kB) | Preview
[img]
Preview
Text
BAB I_IFTITA KHUSSARIROH_FARMASI'18.pdf

Download (540kB) | Preview
[img]
Preview
Text
BAB II_IFTITA KHUSSARIROH_FARMASI'18.pdf

Download (616kB) | Preview
[img] Text
BAB III_IFTITA KHUSSARIROH_FARMASI'18.pdf
Restricted to Repository staff only

Download (581kB)
[img] Text
BAB IV_IFTITA KHUSSARIROH_FARMASI'18.pdf
Restricted to Repository staff only

Download (676kB)
[img] Text
BAB V_IFTITA KHUSSARIROH_FARMASI'18.pdf
Restricted to Repository staff only

Download (543kB)
[img]
Preview
Text
DAFTAR PUSTAKA_IFTITA KHUSSARIROH_FARMASI'18.pdf

Download (555kB) | Preview
[img] Text
LAMPIRAN_IFTITA KHUSSARIROH_FARMASI'18.pdf
Restricted to Repository staff only

Download (1MB)

Abstract

Glibenclamide is an antidiabetic oral that is used to treat Non-Insulin Dependent Diabetes Mellitus (NIDDM). Generic type of glibenclamide is considered low quality drug due to its low price. This research aims to compare dissolution profile of branded glibenclamide tablet and generic types (A and B). Each drug was assessed based on its physical qualities and dissolution profile. Each from tablets brand and generic taked as samples for tablets brand and two samples for tablets generic from circulated market. Used glibenclamide tablets with 5 mg doses. It used to research of physical characteristic tablet and dissolution test. Dissolution test of glibenclamide tablets brand and generic was performed in 900 ml liquid dissolution medium of buffer phosphate pH 6,8 and used dissolution insrument type two with 100 rpm. Based on research of physical characteristics such as uniformity of weight, tablets hardness and disintegration test get that all of physical characteristics glibenclamide brand and generic tablets full fill in prescript qualify, comparative test results between generic A brand glibenclmide tablets showed dissolution profiles similar to f1 =7 and f2=57 values because the f1values were less than 15 and more than 50 while the generic B showed different dissolution profiles with f1 value =47 and f2 =21, because the value of f1 is more than 15 and f2 is less than 50.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Dr. Agus Siswanto. M.Si., Apt., dan Ika Nurzijah, M.Sc., Apt.
Uncontrolled Keywords: Glibenclamide tablets, brand , generic
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Iin Hayuningtyas
Date Deposited: 27 Nov 2018 04:09
Last Modified: 27 Nov 2018 04:09
URI: http://repository.ump.ac.id/id/eprint/8173

Actions (login required)

View Item View Item