AKTIVITAS ANTIINFLAMASI DAN ANTIAGREGASI PLATELET EKSTRAK ETANOL DAUN KUMIS KUCING SECARA IN VIVO DAN IN VITRO

FAJARINI, PUJI ASTY (2012) AKTIVITAS ANTIINFLAMASI DAN ANTIAGREGASI PLATELET EKSTRAK ETANOL DAUN KUMIS KUCING SECARA IN VIVO DAN IN VITRO. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Background: Inflammation is a common symptom experienced by most people. The choice of anti-inflammatory drugs is limited to use the NSAIDs. However the use of these drugs risk of side effects in the gastrointestinal tract. Therefore, the use of natural medicine or traditional medicine could been alternative for the treatment of inflammation. One of the medicinal plants which are widely used for inflammation treatment, is the Orthosiphon stamineus. However, there is no information available for anti-inflammatory mechanism of Orthosiphon stamineus L. Research Objectives: The aim of this study was to determine the antiinflamation and antiagregation activity of ethanol extract of leaves of the orthosiphon stamineus L. Results: In the present study used of six treatment groups in the Na-CMC (solvent control), aspirin (positive control), Na diclofenac (positive control), the dose of 100 mg / kg, 500 mg / kg, and 2500 mg / kg body weight of ethanolic extract of Orthosiphon stamineus L. In vivo test performed by the ear edema and rat paw edema test. Data from both assays, then analyzed statistically by two-way anava followed by the T-Test to compare the results of percent inhibition from those two it resulted that doses of 500 and 2500 mg / kg did not differ significantly with the positive control. From the T-test result, it showed that percent inhibition of inflammation shown in the rat paw edema was greater than in the ear edema test. In vitro test performed by platelet antiagregation which included the bleeding time and absorbance. Antiaggregation test result data were analyzed with one-way anava. From the results of statistical analysis of the bleeding time test and observation of the plasma absorbance changes. From the result of statistical analysis from bleeding time test absorbance changes of plasma using one-way anava, it exhibited that all doses of treatment had no significant different with positive control. Conclusion: Ethanol leaf extract of orthosiphon stamineus L. exhibited antiinflammatory activity at doses of 500 mg/Kg and 2500 mg/kg BW as well as showed antiagregation activity at doses of 100 mg / kg, 500 mg / Kg and 2500 mg / kg body weight.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Binar Asrining Dhiani, M.Sc., Apt dan Susanti, M.Phil, Apt
Uncontrolled Keywords: Orthosiphon stamineus L. , antiinflamatory, platelet agregation, in vivo, in vitro.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Danarto Kh
Date Deposited: 27 Feb 2018 03:18
Last Modified: 27 Feb 2018 03:18
URI: http://repository.ump.ac.id/id/eprint/7448

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