KAJIAN PENGGUNAAN OBAT ANTIHIPERTENSI ORAL PADA IBU HAMIL PREEKLAMSIA RAWAT INAP DI RSUD Prof. Dr. MARGONO SOEKARJO PURWOKERTO

WIGUNA, YAN HAFID (2014) KAJIAN PENGGUNAAN OBAT ANTIHIPERTENSI ORAL PADA IBU HAMIL PREEKLAMSIA RAWAT INAP DI RSUD Prof. Dr. MARGONO SOEKARJO PURWOKERTO. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Background : Preeclampsia is one of the problem that arise in pregnant women. Around 70% pregnant women who were diagnosed with hypertension during pregnancy will suffer gestational hypertension – preeclampsia. Preeclampsia can cause stillbirth in infants and it is still being debated about the main cause. Fetal safety issues make preeclampsia treatment options became limited. Until now, there are three antihypertensive drugs that widely used for preeclampsia treatment, there are nifedipine, methyldopa and labetalol. Objective : This study aims to determine the oral antihypertensive drugs that used in pregnant women with preeclampsia in Prof. Dr. Margono Soekarjo Local Public Hospital of Purwokerto and compare its effectiveness if there are two oral antihypertensive drugs used. Methods : The method of this research is descriptive observational analytic study with cross sectional design and prospective approach and data collection prospectively. Result : From 27 respondents that were obtained, 20 (74,07%) of respondents pregnancy is multigravida and 7 (25,93%) respondents are primigravida. There are 9 (45%) of multigravida respondents who have a high blood pressure history in early pregnancy. Therapy that are used is single and combination. Combination therapy (nifedipine 3x10mg + methyldopa 3x250-500mg) is more widely used in 19 (70.37%) of respondents, while a single therapy (nifedipine 3x10mg) less used only in 8 (29.63%) respondents. The increase in blood pressure during treatment occurred in 1 (3.7%) of respondents who received single therapy and 6 (22.22%) of respondents who received combination therapy (pvalue = 0.633). A total of 3 (11.11%) respondents that were given combination therapy, and 1 (3.7%) of the respondents that were given a single treatment complained of headaches before and after therapy, it is indicating the possibility of side effects (pvalue = 1.000). Conclusion : There is no significant difference between single therapy (nifedipin 3x10mg) and combination therapy (nifedipin 3x10mg + metildopa 3x250-500mg) in lowering blood pressure and lead to the possibility of side effects.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Dr. Tjiptasurasa, S.U. Apt. dan Githa Fungie Galistiani, M.Sc., Apt
Uncontrolled Keywords: preeklamsia; nifedipin; metildopa; preeclampsia; nifedipine; methyldopa;
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Riski Wismana
Date Deposited: 24 Jan 2018 03:24
Last Modified: 24 Jan 2018 03:24
URI: http://repository.ump.ac.id/id/eprint/7314

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