AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL BIJI KECIPIR (Psophocarpus tetragonolobus L.) TERHADAP TIKUS JANTAN GALUR WISTAR

INDRAWATI, NILA (2015) AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL BIJI KECIPIR (Psophocarpus tetragonolobus L.) TERHADAP TIKUS JANTAN GALUR WISTAR. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Inflammation is a body's response to tissue damage caused by microorganisms, mechanical trauma, chemicals and physical influences. Winged bean plants (Psophocarpus tetragonolobus L.) containing flavonoids, a well known anti-inflammatory substances. This study aims to determine the antiinflammatory activity of the ethanol extract of winged bean seed. This is an experimental research. Winged bean seed powder is extracted by maceration using ethanol solvent. Antiinflammatory activity test was carried out by rat hind paw edema induced by carrageenan. Five different groups were used, and winged bean seed extracts were given at doses of 200, 400 and 600mg/kg. Diclofenac Na was used as a positive control at dose of 6,3mg/kg and Na CMC was used as negative control. Formed edema volume ware measured using a plethysmometer and its thickness were measured used caliper. The results showed that the percent of inhibition inflammation measured by pletismometer and calipers are 63.57% and 40.36% for positive control, 35.27% and 30.94% for the extract 200mg / kg, 48.97% and 33.5% for the extract 400mg / kg BB, 50,35% and 39.47% for the extract 600mg / kg. The results showed that the winged bean seed ethanolic extract has anti-inflammatory activity in minute 180.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Dwi Hartanti, M.Farm., Apt dan Susanti, M.Phil.
Uncontrolled Keywords: Anti-inflammatory, winged bean, methods of rat hind paw edema, sodium diclofenac
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Danarto Kh
Date Deposited: 09 Feb 2017 03:42
Last Modified: 09 Feb 2017 03:42
URI: http://repository.ump.ac.id/id/eprint/696

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