Background:The increasing number of Tuberculosis patients is a major factor for
the mortality in Indonesia. One of the leading factors is the mediacation span
which goes through for a month. The long medication leads into a stability
problem for the drugs stored in the period either physically or chemically. Based
on the previous studies, it was found out an interaction of rifampicin and
isoniazid, which with an addition of pyrazinamid in the combination can speed up
the reaction between the two substances.
Objective: This study is conducted to reveal the problem of phyiscial and
chemical stabilities of isoniazid and pyrazinamid in the combination of the
provided pulveres which is stored in a month in a room temperature.
Methods: The research methods applied was an experimental approach using One
Group Pretest Posttest design and the analysis method used was one way Anova.
Result: The physical stability of the combination of the the medicine provided
organoleptically does not show any change ( color, shape, and odor ). However,
chemically it shows a decrease of content in each sample due to the long period of
the world in which Indonesia is grouped in zone VI, with a hot and humid climate.
The statistical test made indicates a significant difference ( p<0,05) of the content
decrease of each medicine relative to the storage period.
Conclusion:The medication of tuberculosis in such a period arrangement is
proved to adversely influence the content. It decreases the content of the substance
by the month period in an average temperature of 27,50C.