VALIDASI METODE ANALISIS METOPROLOL DALAM URIN MANUSIA SECARA KROMATOGRAFI LAPIS TIPIS DENSITOMETRI

ESTIKA, DENILLA (2017) VALIDASI METODE ANALISIS METOPROLOL DALAM URIN MANUSIA SECARA KROMATOGRAFI LAPIS TIPIS DENSITOMETRI. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Lifestyle of the day lately often cause many diseases such as hypertension. One of the drugs used to treat hypertension was metoprolol. In long-term used, metoprolol need monitored to detect early symptoms of side effects. There was validation metoprolol of analysis in human urine by thin layer chromatography (TLC) – Densitometry method. The method that used in this research was in vitro. The stationary phase was silica gel 60 F254 while the mobile phase was consist of chloroform: methanol: ammonia (40: 60: 0,2) v / v. Detection was done with wavelenght 282 nm. Validation parameters include of Limit of Detection (LOD) value was 4,473 μg while Limit of Quantification (LOQ) value was 14,90 μg, linearity was indicated by r = 0,9904. Precision was showed with Relative Standart Deviation (RSD) value of 4.07%. The result showed that value of recovery was 102.73%. The result showed that thin layer chromatography- Densitometry method could be used for the analysis of metoprolol in human urine in vitro.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Dr. Pri Iswati, M.Si.,Apt. dan Dr. Asmiyenti Djalil D, M.Si.
Uncontrolled Keywords: Validation analysis method, thin layer chromatography, densitometry, metoprolol, in vitro,urine
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Danarto Kh
Date Deposited: 19 Sep 2017 02:03
Last Modified: 19 Sep 2017 02:03
URI: http://repository.ump.ac.id/id/eprint/4221

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