EVALUASI KONDISI PENYIMPANAN DAN CEMARAN MIKROBA PADA SIRUP AMBOROXOL HYDROCLORIDE DI APOTEK WILAYAH PURWOKERTO

TAMA, NURHAFIZA (2017) EVALUASI KONDISI PENYIMPANAN DAN CEMARAN MIKROBA PADA SIRUP AMBOROXOL HYDROCLORIDE DI APOTEK WILAYAH PURWOKERTO. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

The quality of a drug should always be maintained from its production until it is consumed by the patient. Drugs whose quality are not maintained can affect the effectiveness of therapy and a possibility of microbial contamination. A good non-sterile syrup preparation that is a syrup that must meet the quality requirements. The requirement of microbial contamination in maximum nonsterile syrup is no more than 〖10 ^3 colony/ g or colony/ mL. This research aims to know the microbial contamination of Ambroxol Hydrochloride syrup according to the storage condition in Pharmacies (Apotek) in the regency of Purwokerto and to know the microbial contamination of Ambroxol Hydrochloride syrup at the first opened syrup. This research is non-experimental with a descriptive analytical approach. The examination of microbial contamination uses total plate count method. The compatibility percentage of storage condition is the provided by the Indonesian department of Health (2007). The average percentage of all Medicine Storage is 86.69% which constitutes a good number. The highest compatibility percentage are in pharmacies XI, XVIII, XIX, XXVI and XXX in the area of Purwokerto which represents 100% and the lowest are for Pharmacies III and IX whit only 72,72%. The examination of total plate countgives us the satisfying result that the contamination of Ambroxol Hydrochloride syrup in the Banyumas Regency is very low at the first opened syrup, furthermore the increase of contamination at the first opening remains within the allowed limit of <103 (FIP, 1975). The result of this correlation test between the storage condition and the number of colony gets a score of p> 0.05, which means there is no relation between the condition of storage and the number of colony. From those explanations above, it can be concluded that the storage condition can not influence the microbial contamination in the stored medicine.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Dr. Nunuk Aries Nurulita, M.Si., Apt dan Erza Genatrika, M.Si.,Apt.
Uncontrolled Keywords: Storage conditions,Pharmacies, Microbial Contamination, Ambroxol Hydrochloride syrup
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Iin Hayuningtyas
Date Deposited: 16 Sep 2017 00:26
Last Modified: 16 Sep 2017 00:26
URI: http://repository.ump.ac.id/id/eprint/4149

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