FORMULASI, STABILITAS, DAN AKTIVITAS PENANGKAPAN RADIKAL BEBAS SEDIAAN MASKER GEL EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.)

MAYANA, WITAR (2017) FORMULASI, STABILITAS, DAN AKTIVITAS PENANGKAPAN RADIKAL BEBAS SEDIAAN MASKER GEL EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.). Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Ethanolic extracts of the soursop (Annona muricata L.) leaves has a free radical scavenging activity with IC50 of 38.8362 ppm. The purpose of this study to determine physical properties, stability and the free radical scavenging activity of the ethanol extract of soursop leaves gel. Soursop leaves was extracted using 96% ethanol with maceration method. Extract was formulated into 3 gel formulas with concentration of 0,02; 0,3; and 4,5% using PVA base. Gel tested for physical properties, stability for 28 days storage and free radical scavenging activity with DPPH (1,1-diphenyl-2 picrylhydrazyl). The results showed that ethanol extract of soursop leaf gel does not meet the requirements of pH, but qualified on the viscosity and drying time. Ethanolic extract of soursop leaf gel is not stable during of 28 days storage because of a change its organoleptic, pH, and viscosity. Ethanolic extract of soursop leaf gel has a free radical scavenging activity. At concentration of 4,5% has a better free radical scavenging activity than that of innovator product.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Dwi Hartanti, M.Farm.,Apt dan Arif Budiman, MPH.,Apt
Uncontrolled Keywords: soursop (Annona muricata L.), gel, antioxidant, physical properties, stability
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Danarto Kh
Date Deposited: 29 Aug 2017 03:53
Last Modified: 29 Aug 2017 03:53
URI: http://repository.ump.ac.id/id/eprint/3625

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