UJI EFEKTIVITAS EKSTRAK ETANOL PURWOCENG (Pimpinella pruatjan Molk) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH YANG DIINDUKSI ALOKSAN

SARI, RATNA PURWITA (2014) UJI EFEKTIVITAS EKSTRAK ETANOL PURWOCENG (Pimpinella pruatjan Molk) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH YANG DIINDUKSI ALOKSAN. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Background: Diabetes Mellitus (DM) is a disease characterized by the increase of blood glucose levels (hyperglycemia). Diabetes mellitus requires long-term and expensive treatment. Therefore, research on finding new and affordable plant derived subtances to treat DM is necessary. Objective: The aim of this study is to determine the hypoglycemic effect of purwoceng herb ethanol extract (Pimpinella pruatjan Molk) against alloxan-induced rats. Methods: The type of this study is experimental, randomized pretest and posttest with control group design. Result: On Na CMC group the blood glucose level of the rats did not decline and were significantly different to blood glucose levels of glibenclamide group. Blood glucose levels of glibenclamide group decreased until reaching the normal value. Blood glucose levels of 12,5 mg/KgBB purwoceng ethanol exract (EEP) group decreased and were comparable with blood glucose levels of glibenclamide group. Blood glucose levels of 25 mg/KgBB EEP group decreaced and were also comparable with blood glucose levels of glibenclamide group. Similarly, blood glucose level of 50 mg/KgBB EEP group decreased and were comparable with blood glukcose levels of glibenclamide group. Conclusion: Each dose of purwoceng ethanol extract (Pimpinella pruatjan Molk) showed the effect on decreasing blood glucose levels of rat (hypoglycemic activity).

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Susanti, S.Farm., M.Phil., Apt. dan Retno Wahyuningrum, S.Farm., M. Si., Apt.
Uncontrolled Keywords: Diabetes melitus, penurunan kadar gula darah, hipoglikemik, ekstrak etanol purwoceng, Diabetes Mellitus, decreasing of blood sugar levels, hypoglycemic, purwoceng ethanol extract.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Riski Wismana
Date Deposited: 12 Jul 2017 04:15
Last Modified: 12 Jul 2017 04:15
URI: http://repository.ump.ac.id/id/eprint/2609

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