HUBUNGAN KUANTITATIF STRUKTUR DAN AKTIVITAS ANTIKANKER SENYAWA TURUNAN BAKTERIOFEOFORBID A

YULIANTO, TEDY (2014) HUBUNGAN KUANTITATIF STRUKTUR DAN AKTIVITAS ANTIKANKER SENYAWA TURUNAN BAKTERIOFEOFORBID A. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

method. In another test, the modifications of photosensitizer with addition an amino acid such as arginine, serine and lysine, also 1-hydroxyethyl can enhance the effectiveness of anticancer compounds. Objective : This study aimed to determine the quantitative relationship of structure and activity of bacteriopheophorbide a derivatives as anticancer, QSAR equation determines the shape of bacteriopheophorbide a derivatives which can be selected and used in the modeling, as well as bacteriopheophorbide a derivative compounds that have anti-cancer activity higher. Methods : The method of computing using the software ChemDraw, Gaussian, and the Molecular Operating Environment (MOE). Results : IC50 value obtained prediction is serine bakteriofeoforbid a (0.0000301 ng/mL), 1-hydroxyethyl bakteriofeoforbid a (0.001778 ng/mL), lysine bakteriofeoforbid a (0.005888 ng/mL), arginine bakteriofeoforbid a (0.008892011 ng/mL), and bakteriofeoforbid a (0.012246161 ng/mL). The combination bakteriofeoforbid compounds with amino acids makes this compound more potent in treating cancer. This can be seen from the IC50 values derived bakteriofeoforbid a smaller than the IC50 value bakteriofeoforbid a. Conclusion : Compounds of derivative bacteriopheophorbide a predicted have potential as anti-cancer better is bacteriopheophorbide a serine compounds with IC50 values 0.0000301 ng/mL.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Dr. Asmiyenti Djaliasrin Djalil, M.Si dan Suparman, M.Sc., Apt
Uncontrolled Keywords: Cancer, bacteriopheophorbide a, photosensitizer, photodynamic therapy, QSAR
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Danarto Kh
Date Deposited: 08 Jul 2017 02:36
Last Modified: 08 Jul 2017 02:36
URI: http://repository.ump.ac.id/id/eprint/2433

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