EFEK DIURETIK EKSTRAK ETANOL BUAH DAN DAUN SUKUN (Artocarpus altilis (Parkinson) Fosberg) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR

SARI, ASIH ARUM (2014) EFEK DIURETIK EKSTRAK ETANOL BUAH DAN DAUN SUKUN (Artocarpus altilis (Parkinson) Fosberg) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Introduction: Diuretic is a drug dealer that can increase the volume of urine or urinary flow rate by increasing the excretion of water and Na+. The clinical usefulness of diuretics is used for the treatment of hypertension, heart failure kongesif, kidney failure and many others. In the treatment of hypertension have been used such as diuretic (35.5%), Captropil (26.2%), valsatran (20.6%), amlodipine (15.2%) and other antihypertensive drugs (2.5%). Community in addition to using modern diuretics also use the plant as medicine, including drugs for launch urine (diuretic). One of the plants empirically used diuretic drug are artocarpus altilis (Parkinson) Fosberg which known as fruit bread or breadfruit. Fruit and breadfruit leaves are used as a diuretic, cure heart failure, hypertension and kidney. Object: This study aimed to investigate the diuretics effects on ethanol extract of of fruit and breadfruit leaves on male white rats of the wistar strain, and be completelly to comparing diuretics effects on variations in dose ethanol extract them on male white rats of the wistar strain. Method: This study is an experimental post-test only control group design to measure the volume of urine after treatment some groups (control and treatment). The study was conducted by giving a positive control, negative control, treatment of breadfruit ethanol extract. Provision has been made by way of orally treatment to test animals. Result: Base on the research have conclussion that various doses given to rats, dose of breadfruit ethanol extract showed no significant difference with the dose furosemide of 5.2 mg / kg, it meaning has a diuretic effect. Ethanol extract of breadfruit leaves did not significantly differrent from dose furosemide 11mg/kg, this menaing has a diuretic effect. Conclusion: Base on the results can conclude that ethanol extract of the leaves and breadfruit has a diuretic effect on white male rats wistar strain. Ethanol extract of breadfruit produce a diuretic effect is higher than ethanol extract leaves of breadfruit.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Dr. Nunuk Aries Nurlita, M.Si., Apt dan Retno Wahyuningrum, M.Si., Apt
Uncontrolled Keywords: leaves of breadfruit, diuretics effects, male rats
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Danarto Kh
Date Deposited: 08 Jul 2017 01:31
Last Modified: 08 Jul 2017 01:31
URI: http://repository.ump.ac.id/id/eprint/2415

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