PENGUJIAN EKSTRAK BIJI LAMTORO (Leucaena leucocephala L) SEBAGAI PENYEMBUH LUKA PADA KULIT KELINCI

AZIZAH, SUCI NUR KHIKMATUL (2015) PENGUJIAN EKSTRAK BIJI LAMTORO (Leucaena leucocephala L) SEBAGAI PENYEMBUH LUKA PADA KULIT KELINCI. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Leucaena leucocephala L is plant is cultivated by Indonesian. It is used tradionally as an alternative medicine wounds sliced and punctured wounds caused by sharp objects. Leucaena leucocephala seed contained active compounds in the form of alkaloids, saponins, flavonoids, tannins, mimiosin, leukanin, protein, fat, calcium, phosphorus, Vit A and B. Where the presence of tannins give effect astringnsia is shrinking pores of the skin, strengthen the skin, stop exudate and mild bleeding in the wound healing process. The purpose of this study was to investigate the potential Leucaena leucocephala seed extract as a wound healing. The method used in this study is the experimental method with a completely randomized design. Where 25 test animals rabbits were divided into 5 groups, namely the cmc 2% as a negative control, povidone iodine 10% as a positive control, a group Leucaena leucocephala seed extract treatment with dose concentration of 5%, 10% and 20%. Treatment was given two times a day as much as 1 g for 21, On day 7 and 21, were tested to determine the number of histopathology fibroblast and collagen. Results showed that the extract concentration of 5% the result is more optimal than the treatment group the extract concentration of 10% and 20%, and positive and negative control group. The conclusion that Leucaena leucocephala seed extract concentrations of 5% has the effect of wound healing by increasing wound contraction, the number of fibroblasts and collagen high scores.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Susanti, M Phil, Apt dan Retno Wahyuningrum S, Farm., M.Si., Apt
Uncontrolled Keywords: Extract Leucaena leucocephala, wound healing, the total score of fibroblast and collagen
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Danarto Kh
Date Deposited: 24 May 2017 01:01
Last Modified: 24 May 2017 01:01
URI: http://repository.ump.ac.id/id/eprint/1976

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