PENGUJIAN EFEK EKSTRAK DAUN LAMTORO (Leucaena leucocephala) TERHADAP PENYEMBUHAN LUKA PADA KULIT KELINCI

PUSPITA, WINDA (2015) PENGUJIAN EFEK EKSTRAK DAUN LAMTORO (Leucaena leucocephala) TERHADAP PENYEMBUHAN LUKA PADA KULIT KELINCI. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Wound is a discontinuity in a tissue, some people prefer to heal the wound traditionally using herbs. One of the herbs used for it is a leave of Leucaena leucocephala (Lam) de Wit. Besides the empirical evidences for healing the wound, the herbs still have other benefits for health. This research is to determine the potency of the ethanol extract of the leave and to determine it’s most effective concentration for healing the wound. This in an experimental research. It’s ethanol extract of Leucaena leucocephala was obtained by maceration extract using the 95% ethanol. The extract were then administrated topically in three distinct consentration of 5%, 10%, and 20% in 2% Na CMC. Each extract was than tested on the excision wound of 2,5 cm in diameter on rabbit’s back. Based on the anova statistics, it indicates that the concentration of 20% shows a very significant result compare to the negative control (p ≤ 0,01). Concentration of 5% and 10% not show any significant result (p ≥ 0,05) and between the concentration of 20% with a positive control is not significant differences. A histopatology test proves that the 20% concentration of the extract has the best score of collagen and of fibroblast quantity compared to other concentrations. It can be concluded that the ethanol extract of the Leucaena leucocephala leaves can speed up the healing of the wound and the most effective concentration is 20%.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Susanti, M.Phil., Apt dan Retno Wahyuningrum, M.Si., Apt
Uncontrolled Keywords: leaves of Leucaena leucocephala (Lam) de Wit, ethanol extract, wound healing
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Danarto Kh
Date Deposited: 08 May 2017 02:22
Last Modified: 08 May 2017 02:22
URI: http://repository.ump.ac.id/id/eprint/1851

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