FORMULASI SABUN CAIR ANTIKEPUTIHAN DARI EKSTRAK ETANOL DAUN KETEPENG CINA (Cassia alata L.)

PRASETYA, NANDA FIRDAUS (2015) FORMULASI SABUN CAIR ANTIKEPUTIHAN DARI EKSTRAK ETANOL DAUN KETEPENG CINA (Cassia alata L.). Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Leucorrhoea is a vaginitis desease which mostly caused by Candida albicans. The treatment to cure the infection of C. Albicans is generally could be executed by using some azole type of drugs, yet recently it is reported that C. Albicans has been resistant to that azole type of drugs. The treatment also can be done by using traditional medicine made of plants which empirically are used as an antifungal potion. It is known that the Cassia alata leaves has an antifungal activity. The research purpose is to discover the antifungal activity of the liquid soap which contains Cassia alata leaves ethanol extract and to find out the effect of the extract concentration to the characteristic of the liquid soap. The extract is gained through the process of maceration using ethanol 96%. The formula of liquid soap is made with the concentration of condensed extract 1,25% as the formula I, 2,5% as the formula II, 5% as the formula III. The evaluation of the liquid soap characteristic is covering organoleptic, viscosity, power foam, and pH. The antifungal activity test of liquid soap formula is done by applying diffusion method using paper disc. The result of the liquid soap characteristic test shows that the variation of extract concentration does not affect the stability of the power foam and pH, however it does affect the formula’s colour and viscosity. The storage process for 4 weeks shows that the formula’s organoleptic characteristic, viscosity, and pH are stable. The antifungal activity test shows that the average diameter of the liquid soap inhibition zones with extract concentration 1.25%, 2.5%, and 5% to C. Albicans in a row are 24.12445 mm, 24.4 mm, and 24.96667 mm, while the positive control is 10.38 mm and the negative control is 23.47778 mm each of them. The liquid soap which contains the extract of Cassia alata leaves has the antifungal activity to the C. albicans. The variation of the extract concentration affects the characteristic of the liquid soap, that is, it affects the formula’s colour and viscosity.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing : Indri Hapsari, M.Si., Apt. dan Arif Budiman, MPH., Apt.
Uncontrolled Keywords: Cassia alata leaves ethanol extract, liquid soap, antifungal, Candida albicans
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Danarto Kh
Date Deposited: 08 May 2017 02:06
Last Modified: 08 May 2017 02:06
URI: http://repository.ump.ac.id/id/eprint/1847

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