EFEK SEDATIF FRAKSI ETIL ASETAT BIJI OROK-OROK (Clotalaria juncea L.) PADA MENCIT

PUTRA, BAYU SATRIA NUGROHO (2016) EFEK SEDATIF FRAKSI ETIL ASETAT BIJI OROK-OROK (Clotalaria juncea L.) PADA MENCIT. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Insomnia is a disorder in which sufferers experience an inability to get enough sleep, both in quality and quantity. In the village of Lembarawa, Brebes, ordinary insomnia was treated empirically using Crotalaria Juncea L. The purpose of this study was to prove that the seeds of Crotalaria juncea L. had potential as a sedative and to test the dose variation ethyl acetate fraction Crotalaria juncea seeds as a sedative. The design of the study was experimental with form posttest-only control group design. A total of 18 mice used were devided into 6 groups. Group I obtained positive control (phenobarbital 60 mg/kg BB), the negative control was group II (Na CMC 1 % ), group III was ethyl acetate fraction (7,5 mg/kg BB), group IV was ethyl acetate fraction (15 mg/kg BB), ethyl acetate fraction was on group V (22,5 mg/kg BB), group VI was ethyl acetate fraction (30 mg/kg BB). In minute 15, 30, 60 and 120 were observed changes in diameter of the pupil of the eye, turnaround of body reflexes, decrease mice grasp and total of mice falling in rotarod for 2 minutes. The number fell mice were statistically analyzed using one way ANOVA test with SPSS 16.0 for windows. Results of statistical analysis showed that the power falls showed a difference between dose variation and the positive control with value p=0,000 (p>0,05). Descriptive results showed that variation ethyl acetate fraction doses obtained a sedative activity but not as good as positive control. It can be indicate that the ethyl acetate fraction of Clotalaria juncea seeds presented a potential sedative effect. The dose of ethyl acetate fraction 22,5 mg/kg BB give the best effect compared to the other dose variation.

Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Dr. Asmiyenti Djaliasrin Djalil, M.Si. dan Erza Genatrika, M.Sc., Apt.
Uncontrolled Keywords: Clotalaria juncea seeds, a sedative effect, extracts methanol, ethyl acetate fraction
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Farmasi > Farmasi
Depositing User: Danarto Kh
Date Deposited: 15 Apr 2017 03:32
Last Modified: 15 Apr 2017 03:32
URI: http://repository.ump.ac.id/id/eprint/1612

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